Genetic manipulation of schistosomes – progress with integration competent vectors

Obesity: Progress through genetic manipulation

Transgenic mice have been produced that either lack or overproduce neuroregulatory substances implicated in the control of food intake and body weight. Are such mice useful models for understanding the underlying etiology of obesity in humans?

Genetic manipulation of endothelial cells by viral vectors.

The need for uncovering molecular mechanisms in endothelial cell biology has tremendously increased in the last decades as it became more and more clear that the endothelium is an important target in nearly all diseases and treatments (drug delivery) and plays a central role in regeneration processes. One of the critical methods generally applied in cell biology research to uncover structural a...

Integrated self-inactivating lentiviral vectors produce full-length genomic transcripts competent for encapsidation and integration.

To make human immunodeficiency virus type 1 (HIV-1)-based vectors safer for use in the research and clinical setting, a significant modification to the HIV-1 genome has been the deletion of promoter and enhancer elements from the U3 region of the long terminal repeat (LTR). Vectors containing this deletion are thought to have no LTR-directed transcription and are called self-inactivating (SIN) ...

Escaping Hierarchical Traps with Competent Genetic Algorithms

Design Process Sequencing With Competent Genetic Algorithms

In product design, it is critical to perform project activities in an appropriate sequence. Otherwise, essential information will not be available when it is needed, and activities that depend on it will proceed using assumptions instead. Later, when the real information is finally available, comparing it with the assumptions made often precipitates a cascade of rework, and thus cost and schedu...